The Resource Vascular smooth muscle metabolism and pyruvate dehydrogenase, by Kathryn R. Ward, (electronic resource)

Vascular smooth muscle metabolism and pyruvate dehydrogenase, by Kathryn R. Ward, (electronic resource)

Label
Vascular smooth muscle metabolism and pyruvate dehydrogenase
Title
Vascular smooth muscle metabolism and pyruvate dehydrogenase
Statement of responsibility
by Kathryn R. Ward
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
In dyslipidemic states, most muscle types preferentially utilize fatty acids rather than glucose largely due to modulation of the pyruvate dehydrogenase complex (PDH) activity by pyruvate dehydrogenase kinase (PDK). We have previously shown that vascular smooth muscle (VSM) does not exhibit a decrease in glucose utilization during exposure to increased levels of either short or long chain fatty acids. To determine if the metabolic inflexibility of VSM may be due to differences in the PDH regulatory mechanisms compared to other muscles, we examined the effects of the PDK inhibitor dichloroacetate (DCA) and the PDP stimulator D-chiro-inositol (DCI) on glucose utilization and lactate production in hog carotid artery (HCA). We also performed western blot analyses of hog skeletal muscle and hog VSM PDK isoforms. In the presence of DCA, a decrease in glucose utilization was observed. Western blot analyses revealed that there is 2.8 fold more PDK3 and 3.2 fold less PDK2 in VSM compared to skeletal muscle. Glucose utilization was significantly increased in the presence of insulin and DCI in VSM. The presence of PDK3 and the relative insensitivity of HCA to DCA suggests that the PDK isoforms present in VSM may contribute to the metabolic inflexibility of this tissue. Therefore, we conclude that PDH in VSM is chronically inhibited by the presence of PDK-3 and this inhibition of PDH may contribute to the metabolic inflexibility of VSM during dyslipidemia, potentially making VSM susceptible to lipotoxicity and atherosclerosis
Cataloging source
MMU
http://library.link/vocab/creatorDate
1985-
http://library.link/vocab/creatorName
Ward, Kathryn R.
Degree
M.S.
Dissertation year
2009.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
NLM call number
WE 500
http://library.link/vocab/relatedWorkOrContributorName
Hardin, Christopher D.
http://library.link/vocab/subjectName
  • Muscle, Smooth, Vascular
  • Pyruvate Dehydrogenase Complex
  • Atherosclerosis
  • Dichloroacetic Acid
  • Dyslipidemias
  • Glucose
  • Inositol
  • Lipid Metabolism
  • Protein-Serine-Threonine Kinases
Target audience
specialized
Label
Vascular smooth muscle metabolism and pyruvate dehydrogenase, by Kathryn R. Ward, (electronic resource)
Instantiates
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on January 26, 2011)
  • Vita
  • Thesis advisor: Christopher D. Hardin
  • "July 2009"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
698365822
Extent
1 online resource (ix, 50 pages)
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
MU: Access is limited to the campuses of the University of Missouri.
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)698365822
Label
Vascular smooth muscle metabolism and pyruvate dehydrogenase, by Kathryn R. Ward, (electronic resource)
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on January 26, 2011)
  • Vita
  • Thesis advisor: Christopher D. Hardin
  • "July 2009"
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
698365822
Extent
1 online resource (ix, 50 pages)
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
MU: Access is limited to the campuses of the University of Missouri.
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
(OCoLC)698365822

Library Locations

    • Thomas Jefferson LibraryBorrow it
      1 University Blvd, St. Louis, MO, 63121, US
      38.710138 -90.311107
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