The Resource Yesinia pestis YopK contributes to immune evasion and cell death to promote plague, by Kristen N. Peters

Yesinia pestis YopK contributes to immune evasion and cell death to promote plague, by Kristen N. Peters

Label
Yesinia pestis YopK contributes to immune evasion and cell death to promote plague
Title
Yesinia pestis YopK contributes to immune evasion and cell death to promote plague
Statement of responsibility
by Kristen N. Peters
Creator
Author
Subject
Genre
Language
eng
Summary
YopK is a 21-kilodalton protein that is secreted and translocated by the type three secretion system of Yersinia pestis, the causative agent of pneumonic, bubonic, and septicemic plague. This protein has previously been found to control the translocation of the other effector proteins into the host cell, suggesting it had a regulatory function only. We have found that YopK is required for virulence in both a pneumonic and septicemic model of plague in a mouse. During pneumonic plague, YopK contributes to apoptosis of both alveolar and interstitial macrophages and modulates the lung environment to allow establishment of bronchopneumonia, including manipulation of inflammation involving macrophages, dendritic cells, B cells, and CCR2+ populations. These CCR2+ cells and B cells contribute to bacterial clearance and promote the resolution of inflammation during pneumonic plague. Surprisingly, YopK also aided in suppressing all populations of CCR2+ cells in the lung during early infection, suggesting the biphasic response to pneumonic plague may actually involve an early suppression of immune populations that is at least partially dependent on the presence of YopK. In a structure function analysis of the protein, YopK appears to have a structural similarity to a small GTPase and may be functioning as a GTPase mimic in the host cell to contribute to caspase-3 cleavage. This function involved two charged residues in the putative effector binding site of YopK. These data suggest that YopK is a necessary and multi-functional protein that contributes to the success of Y. pestis during plague
Cataloging source
MMU
http://library.link/vocab/creatorName
Peters, Kristen N
Degree
Ph. D.
Dissertation year
2012.
Government publication
government publication of a state province territory dependency etc
Granting institution
University of Missouri--Columbia
Illustrations
illustrations
Index
no index present
LC call number
QR201.P5
Literary form
non fiction
Nature of contents
  • dictionaries
  • theses
  • bibliography
NLM call number
QW 165.5.P2
http://library.link/vocab/subjectName
  • Bacterial proteins
  • Yersinia pestis
  • Chemokines
  • Cysteine proteinases
  • Bacterial Outer Membrane Proteins
  • Bacterial Outer Membrane Proteins
  • Bacterial Proteins
  • Bacterial Secretion Systems
  • Caspase 3
  • Receptors, CCR2
  • Structure-Activity Relationship
  • Yersinia pestis
  • Yersinia pestis
Label
Yesinia pestis YopK contributes to immune evasion and cell death to promote plague, by Kristen N. Peters
Instantiates
Publication
Contributor
Contributor
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Dissertation advisor: Dr. Deborah Anderson
  • Vita
  • "May 2012."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Control code
864761592
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Note
Access is limited to the campuses of the University of Missouri.
Specific material designation
remote
System control number
(OCoLC)864761592
Label
Yesinia pestis YopK contributes to immune evasion and cell death to promote plague, by Kristen N. Peters
Publication
Contributor
Contributor
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Dissertation advisor: Dr. Deborah Anderson
  • Vita
  • "May 2012."
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier.
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent.
Control code
864761592
Form of item
online
Media category
computer
Media MARC source
rdamedia.
Media type code
  • c
Note
Access is limited to the campuses of the University of Missouri.
Specific material designation
remote
System control number
(OCoLC)864761592

Library Locations

    • Thomas Jefferson LibraryBorrow it
      1 University Blvd, St. Louis, MO, 63121, US
      38.710138 -90.311107
Processing Feedback ...