Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report

Resource Information

The work Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report represents a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries. This resource is a combination of several types including: Work, Language Material, Books.

Label

Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report

Title remainder

final report

Statement of responsibility

Robert D. Johnson, Russell J. Lewis

Creator

• Johnson, Robert D., (Robert David), 1974-

Contributor

• Civil Aerospace Medical Institute
• United States, Office of Aerospace Medicine
• Lewis, Russell J

Subject

• Adrenergic beta blockers -- Analysis
• Adrenergic beta-Antagonists -- analysis
• Aerospace Medicine -- methods
• Aircraft accidents
• Chromatography, Liquid -- methods
• Electronic government information -- United States
• Government publications -- United States
• Hypertension -- Treatment
• Hypertension -- drug therapy
• Mass Spectrometry -- methods
• Propanolamines -- Analysis
• Technical Report
• United States
• Accidents, Aviation

Genre

• Government publications
• Technical Report
• Electronic government information

Language

eng

Summary

Hypertension is a growing medical concern in the United States. With an increasing number of Americans suffering from hypertension every year, the use of antihypertensive medications such as beta-blockers has increased as well. Three beta-blocker medications--atenolol, metoprolol, and propranolol--were among the 200 most prescribed drugs in the United States in 2003, ranked 4, 14, and 165, respectively. Pilots that successfully manage their hypertension either with diet, exercise, and/or medication may remain medically certified to operate an aircraft. However, these pilots are closely monitored to ensure that their hypertension is properly controlled. The FAA classifies approximately 8% of all active civil aviation pilots as "hypertensive with medication." Toxicological evaluation of postmortem samples obtained from pilots is an important part of the investigation of fatal civil aviation accidents. During this evaluation it is not uncommon to detect beta-blocker compounds such as atenolol, metoprolol, or propranolol in the submitted biological samples. In forensic toxicology laboratories, these compounds are most commonly confirmed and/or quantitated by gas chromatography with mass spectrometric detection (GC/MS). Liquid chromatography coupled with mass spectrometric detection (LC/MS), however, is becoming increasingly more prevalent in the field of forensic toxicology and is considered a superior alternative to GC/MS for the analysis of many compounds. There are very few analytical LC/MS methods published for the determination of beta-blockers from biological specimens. Furthermore, we were unable to find any citation for the toxicological determination of beta-blockers in postmortem fluid and tissue specimens using LC/MS; in particular, atmospheric pressure chemical ionization (APCI) in conjunction with ion trap MS. This manuscript describes the validation and application of such a method

Additional physical form

Also available in print.

Cataloging source

NLM

Funding information

Performed by FAA Civil Aerospace Medical Institute under approved task no.

Government publication

federal national government publication

Illustrations

illustrations

Index

no index present

Literary form

non fiction

Nature of contents

• dictionaries
• bibliography
• technical reports

NLM call number

QV 132