The prevention and treatment of missing data in clinical trials

Resource Information

The work The prevention and treatment of missing data in clinical trials represents a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries. This resource is a combination of several types including: Work, Language Material, Books.

Label

The prevention and treatment of missing data in clinical trials

Statement of responsibility

Panel on Handling Missing Data in Clinical Trials, Committee on National Statistics, Division of Behavioral and Social Sciences, National Research Council of the National Academies

Creator

• National Research Council (U.S.), Panel on Handling Missing Data in Clinical Trials

Contributor

• National Research Council (U.S.), Committee on National Statistics

Subject

• BODY, MIND & SPIRIT -- Healing | General
• Biomedical Research -- standards
• Clinical trials -- Statistical methods
• Clinical trials -- Statistical methods
• Electronic books
• Experimental design
• HEALTH & FITNESS -- Alternative Therapies
• HEALTH & FITNESS -- Healing
• MEDICAL -- Healing
• Randomized Controlled Trials as Topic -- statistics & numerical data
• Experimental design

Genre

• Electronic books

Language

eng

Summary

"Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data."--Publisher's description

Member of

• Ebook Central Academic Complete

Cataloging source

N$T

Dewey number

615.50724

Illustrations

illustrations

Index

no index present

LC call number

R853.C55

LC item number

N387 2010eb

Literary form

non fiction

Nature of contents

• dictionaries
• bibliography

NLM call number

• 2011 C-574
• WA 950