Synthesis and evaluation of radioactive gold nanoparticles for cancer treatment and imaging
Resource Information
The work Synthesis and evaluation of radioactive gold nanoparticles for cancer treatment and imaging represents a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries. This resource is a combination of several types including: Work, Language Material, Books.
The Resource
Synthesis and evaluation of radioactive gold nanoparticles for cancer treatment and imaging
Resource Information
The work Synthesis and evaluation of radioactive gold nanoparticles for cancer treatment and imaging represents a distinct intellectual or artistic creation found in University of Missouri-St. Louis Libraries. This resource is a combination of several types including: Work, Language Material, Books.
- Label
- Synthesis and evaluation of radioactive gold nanoparticles for cancer treatment and imaging
- Statement of responsibility
- By Amal Yousif Al-Yasiri
- Language
- eng
- Summary
- The main goal of this dissertation was to explore new protocols to synthesize biocompatible radioactive gold nanoparticles to treat and image cancer and calculate the dose distribution by using MCNP in tumor inside the human prostate as well as surrounding normal tissues. This dissertation is classified into three parts or projects. The objective of the first project is production and evaluation of radioactive MGF- 198AuNPs and MGF- 199AuNPs towards prostate cancer treatment and imaging. Non-radioactive MGF-AuNPs were synthesized first and in vitro evaluated. Results of In vitro evaluation showed that this type of nanoparticles is stable, non toxic, and can be internalized into prostate cancer cells. Next, new modified protocols were developed to produce radioactive MGF- 198AuNPs and MGF- 199AuNPs. UV-Vis spectroscopy and TLC measurements showed that these radioactive MGF- 198AuNPs and MGF- 199AuNPs are stable and more than 96% of radioactive gold was within nanoparticlate structure. Then, MGF- 198AuNPs were in vivo evaluated to investigate their in vivo stability, retention in tumor, and efficacy to cure prostate cancer. The results indicated that MGF- 198AuNPs are stable and have excellent ability to be retained within the tumor up to 24 hours with very minimum leakage to non-target organs. It was also found that radioactive MGF- 198AuNPs have significant therapeutic effect and that they were able to control the tumor size in comparison to control group. The objective of the second project is production and evaluation of radioactive citrate- 199AuNPs as imaging probe for single photon emission computed tomography. In this study, a new protocol was developed to synthesize radioactive citrate- 199AuNPs, UV-Vis spectroscopy and TLC measurements showed that new protocol was successful to produce stable radioactive citrate- 199AuNPs. Also, In vivo evaluation results showed that citrate- 199AuNPs are stable in vivo and therefore, they can be used in imaging procedures. The objective of the third project is estimation, by means of MCNP simulations, the dose distribution delivered by radioactive gold nanoparticles (198AuNPs or199AuNPs) to tumor inside the human prostate as well as to the normal tissues surrounding the tumor, using water and A-150 tissue equivalent plastic phantoms. A simple geometrical model of a human prostate was used, and the dose distribution that is deposited by radioactive gold nanoparticles (198AuNPs or 199AuNPs) was calculated using MCNP. The results showed that the deposited dose by 198AuNPs or 199AuNPs, which are distributed homogenously in the tumor, has maximum value at the tumor region and then decreases toward the normal tissue in the prostate as well as surrounding organs. However, the dose deposited by 198Au is significantly higher than the dose deposited by 199Au at the tumor region as well as normal tissues. Therefore 198Au should be preferred to for therapeutic applications, while should be preferred for 199Au in imaging applications
- Cataloging source
- MUU
- Degree
- PhD
- Dissertation note
- Thesis
- Dissertation year
- 2015.
- Government publication
- government publication of a state province territory dependency etc
- Granting institution
- University of Missouri--Columbia
- Illustrations
- illustrations
- Index
- no index present
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- theses
Context
Context of Synthesis and evaluation of radioactive gold nanoparticles for cancer treatment and imagingWork of
No resources found
No enriched resources found
Embed
Settings
Select options that apply then copy and paste the RDF/HTML data fragment to include in your application
Embed this data in a secure (HTTPS) page:
Layout options:
Include data citation:
<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.umsl.edu/resource/s-9UjWq5CBE/" typeof="CreativeWork http://bibfra.me/vocab/lite/Work"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.umsl.edu/resource/s-9UjWq5CBE/">Synthesis and evaluation of radioactive gold nanoparticles for cancer treatment and imaging</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.umsl.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.umsl.edu/">University of Missouri-St. Louis Libraries</a></span></span></span></span></div>
Note: Adjust the width and height settings defined in the RDF/HTML code fragment to best match your requirements
Preview
Cite Data - Experimental
Data Citation of the Work Synthesis and evaluation of radioactive gold nanoparticles for cancer treatment and imaging
Copy and paste the following RDF/HTML data fragment to cite this resource
<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.umsl.edu/resource/s-9UjWq5CBE/" typeof="CreativeWork http://bibfra.me/vocab/lite/Work"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.umsl.edu/resource/s-9UjWq5CBE/">Synthesis and evaluation of radioactive gold nanoparticles for cancer treatment and imaging</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.umsl.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.umsl.edu/">University of Missouri-St. Louis Libraries</a></span></span></span></span></div>
